How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open ...

Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to vesicle formation. AP-4, an important member of the AP family, plays a key role ...

Researchers from the National University of Singapore (NUS) have successfully applied cryo-electron microscopy (cryo-EM) to unveil the molecular structures of critical protein machines that transport ...

P-type ATPases play essential roles in maintaining ion homeostasis across cellular membranes, yet structural studies of these dynamic membrane proteins are often limited by sample heterogeneity, ...