“You’re on a chemotherapeutic and your oncologist may say that your dosage is X, while a nephrologist is telling you that the proximal tubules in your kidneys can’t handle it. You’re harming them.” ...

In the lab, it's easier to grow simple balls of cells than complex asymmetrical structures with two distinct ends—like the one million filtering units—nephrons—that make up a human kidney. But new ...

Advances in light sheet fluorescence microscopy (LSFM) and tissue clearing have enabled 3D imaging of intact tissue samples; however, the analytical tools for processing these datasets have lagged ...

In this original study, Inage et al. developed a mouse model to ablate nephron progenitor cells during embryonic day 13.5 of gestation without significantly affecting birth weight or other organ ...

A USC Stem Cell-led research team has achieved a major step forward in the effort to build mouse and human synthetic kidneys. In a new paper published in Cell Stem Cell, the scientists describe ...

The kidney, a critical organ for waste filtration and fluid regulation, is the subject of a groundbreaking molecular mapping project that could reshape our understanding of renal health. Despite ...

A group of essential signaling molecules known as the Wnt pathway emerged early in the evolution of multicellular life. Scientists have been studying Wnt actions for four decades to comprehend its ...

A pair of USC Stem Cell mouse studies detail how progenitor cells self-renew, differentiate, and aggregate into early kidney structures, offering insights for the creation of stem cell-based ...