By combining gene engineering, Ca²⁺ imaging, and detailed functional tests, the team shows with high precision that skeletal muscle contraction is mainly DICR-driven. This long-accepted mechanism is ...

Using powerful new visualization technologies, researchers have captured the first 3-D images of the structure of a key muscle receptor, providing new insights on how muscles develop across the animal ...

The giant cytoskeletal protein obscurin, represented in Caenorhabditis elegans by its orthologue UNC-89, plays a pivotal role in organising the intricate architecture of striated muscles. UNC-89 is ...

Skeletal muscle is a dynamic and highly adaptable tissue responsible for voluntary movement, posture and metabolic regulation. Its unique architecture, involving myofibres, satellite cells and a ...

In a serendipitous discovery, UC San Diego researchers using cryo-EM technology captured the first visualizations of the 3-D structure of the muscle acetylcholine receptor in fetal and adult muscles.