The p53-dependent RR small subunit (p53R2) protein, a newly identified member of the ribonucleotide reductase family, plays a key role in the p53-dependent cellular response to DNA. Several recent ...

Primary effusion lymphoma (PEL) is a highly aggressive B-cell malignancy that is closely associated with one of oncogenic viruses infection, Kaposi’s sarcoma-associated herpesvirus. PEL prognosis is ...

Ribonucleotide reductases (RNRs) play a crucial role in cells as the only source of the building blocks needed for DNA replication and repair. They use radical-based chemistry to catalyze the ...

Chemists discover how a single enzyme maintains a cell’s pool of DNA building blocks. The study sheds light on a longstanding puzzle: how a single enzyme known as ribonucleotide reductase (RNR) ...

Ribonucleotides, units of RNA, can become embedded in genomic DNA during processes such as DNA replication and repair, affecting the stability of the genome by contributing to DNA fragility and ...

Association between health-related quality of life (HRQoL) and clinical outcomes in non-metastatic castration-resistant prostate cancer (M0 CRPC): Results from the PROSPER study. This is an ASCO ...

A paper focusing on the role of co-chaperones involved in ribonucleotide reductase (RNR) activity was recently published in PLOS Genetics and made reference to StressMarq’s Mouse Anti-Yeast HSP40, ...